Min Clinic uses three Rejuran products: Rejuran Classic, Rejuran HB plus and Rejuran i. Rejuran Classic and Rejuran HB plus are available in 2 cc or 4 cc plans, while Rejuran i is provided as a 1 cc treatment for the eye area. The appropriate product and volume are selected according to the treatment area, skin condition and treatment goal.
Timing Rejuran before a wedding or event
Avoid scheduling your first Rejuran treatment immediately before an important event. Raised injection points, redness, swelling, tenderness or bruising may remain visible during the initial recovery period.
Raised injection points generally improve within about three days but may remain for up to approximately one week depending on the individual. Redness, mild swelling and tenderness usually settle within several days but may also last for about one week. Bruising, if it occurs, may remain for one to two weeks.
Changes generally begin to become noticeable about one to two weeks after treatment. Because both recovery and response vary between individuals, the schedule should be planned with enough time before the event.
Consultation and treatment at Min Clinic
A senior consultation manager conducts the initial consultation, and the patient’s skin is assessed using an EVE V MUSE analyzer. The doctor then provides a detailed consultation about the treatment area, product and injection plan before performing the procedure.
At Min Clinic, Rejuran and other medical aesthetic procedures are performed directly by a doctor.
Rejuran products used at Min Clinic
All three products are manufactured by PharmaResearch in Korea.
| Product | Main characteristics | Typical treatment plan at Min Clinic |
|---|---|---|
| Rejuran Classic | A PN-based product used for general skin texture, elasticity and fine-line concerns | 2 cc or 4 cc |
| Rejuran HB plus | Contains PN, hyaluronic acid and lidocaine; designed to provide hydration while reducing injection discomfort | 2 cc or 4 cc |
| Rejuran i | A PN-based formulation intended for the thinner skin around the eyes | 1 cc for the eye area |
The product, volume and injection areas are selected after the doctor evaluates the patient’s skin. Rejuran S is not used at Min Clinic.
What the evidence shows
Rejuran is a polynucleotide-based injectable treatment. Purified PN is injected in small amounts into the skin, where it is used to support improvement in skin texture, elasticity and fine lines.
A systematic review published in the Journal of Cosmetic Dermatology in 2025 described the available evidence as low to moderate in quality. Injection areas and techniques varied across the studies, so the review did not establish a single standard treatment protocol.
Individual results vary, and the treatment should not be described as guaranteeing a particular result by a specific date.
Recommended sessions and intervals
The recommended schedule depends on the patient’s skin condition and treatment goal.
A single maintenance treatment may be considered at intervals of approximately twelve weeks. For more intensive care, three treatments may be recommended at approximately two-week intervals.
Changes may begin to appear about one to two weeks after treatment and may last for approximately three to six months. The timing and duration vary according to the patient’s skin type, treatment area and individual response.
Common reactions and downtime
Common temporary reactions may include:
- Injection discomfort
- Raised injection points
- Redness
- Swelling
- Bruising
- Itching
- Tenderness
Raised injection points usually improve within about three days but may last for up to approximately one week. Redness, mild swelling and tenderness generally settle within several days, although they may remain for about one week. Bruising may last for one to two weeks if it occurs.
Less common but important adverse reactions may include persistent nodules or firmness, inflammation, infection, discoloration, herpes reactivation and allergic reactions. Rejuran HB plus contains lidocaine, so patients with a known allergy to lidocaine or other amide-type local anesthetics must tell the clinic before treatment.
Returning to daily activities
Cleansing and makeup are recommended from the following day. Strenuous exercise and sauna use should be avoided for at least three days.
Flying is generally possible on the same day if there are no unusual symptoms. If redness, swelling or discomfort is more pronounced than expected, contact the clinic before traveling.
Information to provide before treatment
Tell the clinic before treatment if any of the following apply:
- You are pregnant or breastfeeding
- You have a known sensitivity to any product ingredient
- You have inflammation, infection or an open wound in the treatment area
- You are currently taking medication
- You recently received another injectable treatment
- You have a history of herpes infection
- You are allergic to lidocaine or another amide-type local anesthetic, particularly if Rejuran HB plus is being considered
Min Clinic does not perform medical aesthetic procedures during pregnancy. Skincare treatments may be available after consultation.
Questions people ask
How far before an event should I have Rejuran?
Leave enough time for raised injection points, redness, swelling or bruising to settle. If this is your first treatment, schedule it well before the event so that you can see how your skin responds. The doctor can recommend an appropriate schedule after assessing your skin.
Which Rejuran product should I choose?
Rejuran Classic, Rejuran HB plus and Rejuran i have different formulations and intended treatment areas. The doctor selects the product and volume according to the treatment area, skin condition, sensitivity and goals.
Is Rejuran HB plus the same as Rejuran Classic?
No. Rejuran HB plus contains PN, hyaluronic acid and lidocaine. Rejuran Classic is a PN-based product without the same combination of ingredients.
Can Rejuran be combined with other treatments before an event?
It may be possible, but combining procedures can change the recovery period. The doctor should determine whether the procedures can be performed together or should be spaced apart.
Who performs Rejuran at Min Clinic?
At Min Clinic, Rejuran is injected directly by a doctor.
How is genuine Rejuran verified?
The genuine Rejuran product selected for the treatment is opened in front of the patient. Min Clinic also displays its Rejuran Official Certified Clinic plaque issued by PharmaResearch.
How do I contact Min Clinic after returning home?
Patients can contact Min Clinic through WhatsApp. Messages are answered as promptly as possible during clinic hours. Keeping your treatment details available can help the clinic respond to your question more accurately.
What this page is based on
- Min Clinic fact-check questionnaire, returned by the clinic (checked 2026-09-17)
- Lampridou et al., *The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review*, Journal of Cosmetic Dermatology, 2025 (checked 2026-09-05)
- PharmaResearch — Rejuran product and official clinic certification information
