Rejuran in Your 40s from Myeongdong: Comparing Products, Dosing, and Downtime in Cheongdam

What Rejuran is—and what it is not

Rejuran is a PN-based injectable skin booster. PN is injected into the skin to support the management of fine lines, skin texture, and elasticity.

For patients in their 40s, it is important to separate changes in skin quality from structural facial laxity. Rejuran may be considered when concerns include fine lines, texture, dryness, or reduced skin elasticity. It is not a substitute for a lifting procedure when the primary concern is deeper tissue laxity, facial contour, or significant sagging.

If both skin quality and laxity are concerns, the doctor should assess them separately and explain whether Rejuran alone is appropriate or whether an energy-based lifting treatment or another procedure should be considered.

What the current evidence does and does not show

A 2025 systematic review published in the Journal of Cosmetic Dermatology examined nine studies involving 219 patients who received PN treatments. The included studies were rated as low to moderate in quality, and the injection sites and techniques varied.

The review reported promising findings related to wrinkles, skin texture, and elasticity. However, the authors also found limited consensus regarding the optimal use of PN treatments and concluded that more rigorous, high-quality studies are needed to confirm effectiveness and safety.

This review evaluated PN treatments in aesthetic medicine broadly. It should not be presented as evidence proving the effects of one specific Rejuran product.

When comparing clinics, consider how clearly each clinic explains the product, planned volume, injection method, possible downtime, and limitations of the available evidence.

How Min Clinic plans Rejuran treatments

At Min Clinic:

* An initial consultation is conducted by a senior consultation manager. * Skin is assessed using an EVE V MUSE analyzer. * The assessment is followed by a face-to-face consultation with the doctor. * Rejuran is manually injected by a doctor rather than administered with an injector device. * The product, volume, treatment area, and injection distribution are selected according to the patient’s skin condition and goals. * Follow-up care and the need for additional treatment are determined according to the patient’s condition and progress.

Consultation time varies depending on the patient’s condition and questions, but patients should generally allow approximately 15 to 30 minutes. International consultations may take longer when interpretation or a detailed explanation of the assessment is required.

Same-day treatment may be possible depending on appointment availability and the doctor’s assessment.

Understanding the Rejuran product range

Rejuran products are manufactured by PharmaResearch Co., Ltd. in Korea. Rejuran should not be treated as one uniform product because the available options have different compositions and intended treatment areas.

* REJURAN®: A PN-based product commonly used for the overall face to manage fine lines, skin texture, and elasticity. * REJURAN® HB: Contains PN, hyaluronic acid, and lidocaine. Hyaluronic acid supports hydration, while lidocaine helps reduce injection discomfort. * REJURAN HB plus®: Contains PN, hyaluronic acid, and lidocaine but is a separate product from REJURAN HB. * REJURAN® i: A PN-based product introduced by the manufacturer for use around the thinner skin of the eye area.

The doctor selects the appropriate product according to the patient’s skin condition, treatment area, and sensitivity to discomfort.

Comparing dosing and product authenticity

Use the same questions when comparing clinics:

* Who performs the injections? * Is the product manually injected or administered with a device? * Which exact Rejuran product is recommended? * How many cc will be used? * Which areas will be treated? * How is the product’s authenticity verified? * What is included in the quoted price? * What downtime should be expected?

At Min Clinic, REJURAN Healer and REJURAN HB are available in 2cc or 4cc treatment plans. REJURAN i is available as a 1cc treatment for the eye area. REJURAN HB plus is treated as a separate product from REJURAN HB.

The selected genuine Rejuran product is opened in front of the patient before treatment. The clinic’s authenticity certificates are also displayed on site. The exact product and planned volume in cc are explained before treatment.

Descriptions such as “full dose” should not replace the actual product name and volume. There is no single standard Rejuran dose that applies to every patient or every treatment area.

Treatment intervals and expected timing

Rejuran treatment schedules vary according to the patient’s skin condition and treatment goals.

At Min Clinic:

* A single treatment may be followed by another session after an interval of approximately 12 weeks. * For intensive care, a series of three treatments at two-week intervals may be recommended.

The doctor determines the appropriate number of sessions and interval after examining the patient’s skin. The three-to-four-week interval used for some other procedures should not be applied automatically to Rejuran.

Changes may begin to become noticeable approximately one to two weeks after treatment. The duration varies among individuals, but results may last approximately three to six months depending on skin condition, skin type, lifestyle, and treatment plan.

Downtime and aftercare

Rejuran is an injectable treatment and may leave temporary visible signs. Patients should not assume that there will be no downtime.

Possible temporary reactions include:

* Small raised bumps or injection marks: Usually settle within approximately three days but may remain for up to one week. * Redness, mild swelling, and tenderness: Usually improve within several days but may continue for approximately one week. * Bruising: If it occurs, it may remain for approximately one to two weeks. * Injection discomfort, itching, or temporary firmness may also occur.

General aftercare guidance:

* Cleansing and makeup: Generally possible from the following day. * Strenuous exercise and sauna use: Resume after at least three days. * Flying: Generally possible on the day of treatment if there are no unusual symptoms.

Less common but important reactions may include persistent nodules or firmness, inflammation, infection, discoloration, herpes reactivation, and allergic reactions.

REJURAN HB and REJURAN HB plus contain lidocaine. Patients with a history of sensitivity to lidocaine or other amide-type local anesthetics should tell the doctor before treatment.

Contact the clinic if symptoms are severe, continue longer than expected, or cause concern.

When Rejuran may not be appropriate

Tell the clinic before treatment if you:

* Are pregnant or breastfeeding * Have a known sensitivity to any product ingredient * Have inflammation, infection, herpes, or an open wound in the treatment area * Have a history of allergic reactions to injectable products * Are sensitive to lidocaine or other amide-type local anesthetics * Are taking medication that may affect treatment or recovery * Recently received another injectable treatment in the same area

Min Clinic does not perform medical aesthetic procedures during pregnancy. Skincare treatments may be available after consultation.

Costs and included services

Rejuran pricing is based on the specific product and injected volume in cc. The price includes skin assessment, cleansing, and topical anesthetic cream.

A separate regenerative laser treatment is not required as part of the standard Rejuran procedure and should not be described as a routine additional charge.

Min Clinic applies the same prices to international and Korean patients and does not charge an additional card-processing fee.

VAT is charged separately from the listed price at the applicable statutory rate. In accordance with Korean tax law, VAT refunds for cosmetic medical services provided to foreign visitors are no longer available for treatments received on or after January 1, 2026. Min Clinic therefore does not process VAT refunds for treatments received from that date onward.

Confirm the exact product, volume, treatment area, included services, and final price before treatment.

Who performs Rejuran at Min Clinic?

Three doctors practice at Min Clinic, two of whom are board-certified specialists. Medical aesthetic procedures, including Rejuran injections, are performed by a doctor. Skincare treatments are provided separately.

Young Soo Min, chief medical director, is an adjunct professor at Hanyang University and formerly served as deputy director of the Gangnam Station branch of NB Clinic. His manufacturer-issued plaques include Top Restylane Injector from Galderma in 2012, Top Radiesse Injector from Merz in 2011, and IDP Specialist from Allergan in 2011.

Min Ji Kim, medical director, is a board-certified specialist and a former director of Apgujeong ORACLE Dermatology Clinic. She has also participated in academic exchanges with clinics in Japan.

Chan Ho Jung, medical director, graduated from the College of Pharmacy at Sungkyunkwan University and the College of Medicine at Hanyang University. He completed his residency at Hanyang University Medical Center and was named a Restylane Expert Injector by Galderma.

For Rejuran, the doctor assesses the patient’s skin condition and treatment area, selects the product and volume, plans the distribution, and performs the injections.

Consultation and language support

A Rejuran consultation includes:

* Initial consultation with a senior consultation manager * EVE V MUSE skin assessment * Face-to-face assessment and consultation with the doctor * Product and volume selection according to skin condition and treatment area * Explanation of expected downtime and aftercare

Patients may attend a consultation without deciding to receive treatment on the same day. Same-day treatment may be possible depending on availability and the doctor’s assessment.

English consultations are provided by the senior consultation manager together with an interpreter by appointment. Chinese and Japanese language assistance is also available.

Appointments for international patients can be arranged through WhatsApp, KakaoTalk, or WeChat. The clinic responds to WhatsApp messages as promptly as possible during clinic hours.

Getting here from Myeongdong Station

The clinic is located on the fourth floor of Daedong Tower at 326 Dosan-daero, near Hakdong Intersection. An Olive Young store is located on the ground floor.

From Myeongdong Station:

* Subway: Take Line 4 to Chungmuro Station, transfer to Line 3, and then transfer to Line 7 at Express Bus Terminal Station to reach Gangnam-gu Office Station. Travel time varies depending on transfers and walking time. * Taxi: Travel time and fare vary depending on traffic, the route, tolls, and late-night surcharges.

Nearby stations:

* Gangnam-gu Office Station: Use Exit 3 or 3-1. * Apgujeong Rodeo Station: Use Exit 5 of the Suin–Bundang Line.

Parking is available in the outdoor lot on the first floor of Daedong Tower. Enter from the alley to the right of the Olive Young store. Valet parking is also available. Contact the clinic for current parking information.

Practical information for international patients

Clinic hours:

* Monday–Thursday: 10:00–19:00 * Friday: 10:00–20:00 * Saturday: 10:00–15:00 * Lunch break: 13:00–14:00 * Closed on Sundays and public holidays

Payment methods:

* Visa * Mastercard * American Express * UnionPay * JCB * Apple Pay * WeChat Pay * Alipay * Cash in Korean won

PayPal is not accepted. Payment may be split across two cards, and there is no card surcharge.

Bring a passport or another form of photo identification to the appointment. Skin analysis results and treatment records are both available upon request. Skin analysis results can be sent by email, and treatment records can be provided as an itemized treatment statement.

How to contact Min Clinic

* Website: https://www.min-clinic.co.kr/ * Clinic phone: +82-2-515-2119 * English WhatsApp: +82-10-3379-9350 * WhatsApp: https://api.whatsapp.com/message/2P2LPJESWKZTE1?autoload=1&app_absent=0 * KakaoTalk: https://pf.kakao.com/_pxgTqE * WeChat: minbeauty * LINE: minclinic

When comparing clinics in Gangnam or Cheongdam, ask the same questions at each clinic: who performs the injections, which product is recommended, how many cc will be used, how authenticity is verified, what downtime to expect, how sessions are spaced, and what the quoted price includes.

Frequently asked questions

Is Rejuran a lifting treatment for people in their 40s?

Rejuran is a PN-based injectable skin booster used to manage concerns such as fine lines, skin texture, and elasticity. It is not a substitute for an energy-based or structural lifting procedure when the primary concern is deeper tissue laxity or significant sagging. A doctor should assess skin quality and facial laxity separately.

How is Rejuran scheduled for maintenance?

A single treatment may be followed by another session after approximately 12 weeks. For intensive care, a series of three treatments at two-week intervals may be recommended. The doctor determines the appropriate schedule according to the patient’s skin condition and goals.

Who performs the injections?

A doctor manually performs Rejuran injections at Min Clinic. Skincare treatments are provided separately.

How much product is used?

REJURAN Healer and REJURAN HB are available in 2cc or 4cc treatment plans. REJURAN i is available as a 1cc treatment for the eye area. REJURAN HB plus is a separate product from REJURAN HB. The doctor selects the appropriate product and volume according to the patient’s skin condition and treatment area.

How can I verify product authenticity?

The selected genuine Rejuran product is opened in front of the patient before treatment. Min Clinic’s authenticity certificates are also displayed on site. The exact product and planned volume in cc are explained before treatment.

What downtime should I expect?

Small raised bumps or injection marks usually settle within approximately three days but may remain for up to one week. Redness, mild swelling, and tenderness generally improve within several days. Bruising, if it occurs, may remain for approximately one to two weeks. Cleansing and makeup are generally possible from the following day.

What does a consultation include?

The visit begins with an initial consultation with a senior consultation manager and an EVE V MUSE skin assessment. This is followed by an assessment and consultation with the doctor. Same-day treatment may be possible depending on appointment availability and the doctor’s assessment.

Can I receive Rejuran during pregnancy?

No. Min Clinic does not perform medical aesthetic procedures during pregnancy. Skincare treatments may be available after consultation.

What does the current evidence say?

A 2025 systematic review included nine studies involving 219 patients who received PN treatments. The studies were rated as low to moderate in quality, and treatment methods varied. The results were promising, but the authors reported limited consensus regarding optimal use and recommended further high-quality research. The review concerned PN treatments broadly rather than one specific Rejuran product.

Sources

* Lampridou et al., The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review, Journal of Cosmetic Dermatology, 2025 — https://pubmed.ncbi.nlm.nih.gov/39645667/ (checked 2026-09-05) * Min Clinic official website — https://min-clinic.co.kr/en/ (checked 2026-09-09) * Min Clinic contact page — https://min-clinic.co.kr/contact/ * Seoul Metropolitan Government transportation information — https://news.seoul.go.kr/traffic/archives/1659